This stuff is technical but critically important to understanding the possible underlying mechanisms by which excess PUFA may be hurting you. If this is confusing you may want to start with the first episode Peter and I did, all of which are at heartandsoil.co.
Petro Dobromylskyj is a veterinarian, trained at the RVC, London University. He was fortunate enough to intercalate a BSc degree in physiology into his veterinary degree. He was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow him to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. He stumbled onto nutrition completely by accident. Once you have been taught to think, it's hard to stop.
0:14:04 Podcast Begins
0:14:46 Last Episode Recap
0:17:20 Why PUFAs drive obesity
0:22:43 Inappropriate insulin sensitivity
0:31:14 Why we have mitochondria
0:41:26 Being right on Q: shaping eukaryotic evolution https://pubmed.ncbi.nlm.nih.gov/27834740/
0:44:14 Mitochondrial satiety signaling
0:50:38 The glycerol phosphate shuttle
1:08:54 Reverse electron transport generating ROS
1:13:58 The Krebs cycle explained
1:22:59 Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692813/
1:23:58 Are carbs the root-cause of metabolic dysfunction?
1:30:31 Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase https://www.researchgate.net/publication/262529290_Metformin_suppresses_gluconeogenesis_by_inhibiting_mitochondrial_glycerophosphate_dehydrogenase
1:38:47 Metformin (01) Insulinhttps://high-fat-nutrition.blogspot.com/2017/07/metformin-01-insulin.html
1:44:29 Optimizing satiety with saturated fat and glucose
1:49:50 Where to Find Peter https://high-fat-nutrition.blogspot.com/
1:50:34 The fates of Pyruvate
1:52:02 Diets could prevent many diseases https://link.springer.com/article/10.1007/s11745-003-1066-0
1:52:52 Metabolism and longevity: Is there a role for membrane fatty acids? https://academic.oup.com/icb/article/50/5/808/639943