In this AMA episode I answer questions from Ben Greenfield about my book, The Carnivore Code. It’s a deep dive into much of the science of an animal-based way eating. Prepare to learn a ton!
8:03 Carnivore diet background, framework
18:25 Is there a magic ratio of fat to protein we should aim for? What is rabbit starvation?
25:53 A Review of Issues of Dietary Protein Intake in Humans
33:01. Is the decline in height and health fully attributable to plant agriculture or could it be due to industrialization?
38:43 Why do present day hunter-gatherers have no access to wild game?
42:54 How do we know that our high stomach acidity was driven by the consumption of animals?
45:09 The Evolution of Stomach Acidity and Its Relevance to the Human Microbiome https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134116
50:51 How do herbivores detoxify plant toxins?
56:34 Coevolution of poisonous plants and large herbivores on rangelands
1:02:09 What are the studies of isothiocyanates in humans?
1:04:39 Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892312/
1:07:03 Why molecular hormesis is bad news
1:14:42 Effect of increasing fruit and vegetable intake by dietary intervention on nutritional biomarkers and attitudes to dietary change: a randomised trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060837/
1:18:03 Green tea extract only affects markers of oxidative status postprandially: Lasting antioxidant effect of flavonoid-free diet https://www.researchgate.net/publication/11310865_Green_tea_extract_only_affects_markers_of_oxidative_status_postprandially_Lasting_antioxidant_effect_of_flavonoid-free_diet
1:20:08 Uric acid and glutathione levels during short-term whole body cold exposure https://pubmed.ncbi.nlm.nih.gov/8063192/
1:21:14 Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans https://www.nature.com/articles/ncomms14337
1:22:58 Is there an acceptable dose of isoflavones?
1:23:53 Goitrogenic and Estrogenic Activity of Soy Isoflavones https://www.jstor.org/stable/3455387?seq=1
1:25:32 Isoflavones: estrogenic activity, biological effect and bioavailability https://www.researchgate.net/publication/233538635_Isoflavones_Estrogenic_activity_biological_effect_and_bioavailability
1:26:48 Low Dietary Soy Isoflavonoids Increase Hippocampal Spine Synapse Density in Ovariectomized Rats https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330193/
1:29:56 Is resveratrol really something we should avoid?
1:31:09 David Sinclair’s work on Resveratrol https://www.ncbi.nlm.nih.gov/pmc/?term=sinclair%2C+david+resveratrol
1:32:02 Resveratrol reduces the levels of circulating androgen precursors but has no effect on, testosterone, dihydrotestosterone, PSA levels or prostate volume. A 4‐month randomised trial in middle‐aged men https://pubmed.ncbi.nlm.nih.gov/25939591/#:~:text=Conclusion%3A%20In%20this%20population%20of,PSA%2C%20testosterone%2C%20free%20testosterone%2C
1:33:03 Placebo-controlled, randomised clinical trial: high-dose resveratrol treatment for non-alcoholic fatty liver disease https://pubmed.ncbi.nlm.nih.gov/26784973/
1:33:53 Prooxidant activity of research all in the presence of copper ions: mutagenicity in plasmid DNA https://www.sciencedirect.com/science/article/abs/pii/S0378427405001190?via%3Dihub
1:35:17 Resveratrol levels and all cause mortality in older community-dwelling adults https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346286/
1:36:16 resveratrol improves vascular function and mitochondrial number but not in glucose metabolism in older adults https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861959/
1:37:29 What are event-related potentials and how are they measured?
1:37:29 Food processing and emotion regulation in vegetarians and omnivores: an event-related potential investigation https://www.sciencedirect.com/science/article/abs/pii/S0195666319300595?via%3Dihub
1:40:54 What really drives insulin resistance?
1:48:37 Dietary stearic acid leads to a reduction of visceral adipose tissue in athymic nude mice https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164353/
1:51:02 dietary stearic acid regulates mitochondria in vivo in humans https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081440/
1:53:52 What would you change in your diet if you had cancer?
1:56:03 Halted Progression of Soft Palate Cancer in a Patient Treated with the Paleolithic Ketogenic Diet Alone: A 20-months Follow-up http://pubs.sciepub.com/ajmcr/4/8/8/
1:57:29 Complete Cessation of Recurrent Cervical Intraepithelial Neoplasia (CIN) by the Paleolithic Ketogenic Diet: A Case Report
1:58:47 Are there any studies looking at telomere length in plant vs animal food diets?
2:00:10 Processed meat, but not unprocessed red meat, is inversely associated with leukocyte telomere length in the Strongheart family study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037876/
2:00:41 Epigenetic clock analysis of diet, exercise, education, and lifestyle factors https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361673/
2:00:54 Effects of diet on telomere length: systematic review and meta-analysishttps://www.karger.com/?DOI=10.1159/000486586
2:02:00 Dietary intervention modifies DNA methylation age assessed by epigenetic clock https://doi.org/10.1002/mnfr.201800092
2:04:21 Increased lean red meat intake does not elevate markers of oxidative stress and inflammation in humans https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/137.2.363
2:07:40 Would eating fruit without the seeds be a healthy choice?
2:08:07 Why does CarnivoreMD prefer unrendered fat?
2:00:37 Is dietary saturated fat something to be concerned about?